Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression. Therefore, understanding what activates ERα is critical for cancer treatment in particular and cell biology in general.
In this interdisciplinary work, a collaboration led by Dr. Marina Simian from the National University of San Martín (UNSAM, Buenos Aires, Argentina), a key mechanism in the regulation of ERα is described.
We contributed with superresolution microscopy to determine the interaction of ERα with β1-integrin. To do these experiments, Rocío Sampayo (postdoc in the group of Dr. Simian), came to our labs and adapted her cellular models to perform two-color dSTORM measurements on them.
Journal of Cell Biology 217(2018) 2777-2798
“Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells”
Rocío G. Sampayo, Andrés M. Toscani, Matthew G. Rubashkin, Kate Thi, Luciano A. Masullo, Ianina L. Violi, Jonathon N. Latkins, Alfredo Cáceres, William C. Hines, Federico Coluccio Leskow, Fernando D. Stefani, Dante R. Chialvo, Mina J. Bissell, Valerie M. Weaver, Marina Simian.
