Detecting single molecules is the ultimate detection limit. Among other applications it enables measurements beyond ensemble averaging, ultraprecise analytics and super-resolution imging.

Typically, detecting single fluorescent molecules has required costly, research-grade equipment. In our latest publication we present an inexpensive setup that leverages current smartphone technologies to detect single molecules.

This project was led by our close and long-standing collaborator Prof. Guillermo Acuna from the University of Fribourg, Switzerland:

Photonic Nanosystems @ Uni Fribourg  

Morgane Loretan, Mariano Barella, Nathan Fuchs, Samet Kocabey, Karol Kołątaj, Fernando D. Stefani & Guillermo P. Acuna

“Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope”

Nature Communications   16 (2025) 8937